polo-like kinase (plk) — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T16560	Poloxin		PLK
	Poloxin is a non-ATP competitive Polo-like Kinase 1 inhibitor. It targets the polo-box domain (IC50: appr 4.8 μM).		PLK
T3643	HMN-176		PLK
	HMN-176 is a stilbene derivative which inhibits mitosis, interfering with polo-like kinase-1 (plk1).		PLK
T10215	AAPK-25		Apoptosis , PLK , Aurora Kinase
	AAPK-25 is a potent and selective Aurora/PLK dual inhibitor with anti-tumor activity, which can cause mitotic delay and arrest cells in prometaphase, followed by a surge in apoptosis. AAPK-25 targets Aurora-A/-B/-C with ...		Apoptosis , PLK , Aurora Kinase
T15454	GW843682X	GW843682	VEGFR , PLK , CDK , PDGFR , Aurora Kinase
	GW843682X (GW843682) is a selective and ATP-competitive inhibitor of PLK1 and PLK3 (IC50s = 2.2 nM and 9.1 nM).		VEGFR , PLK , CDK , PDGFR , Aurora Kinase
T6217	LFM-A13		PLK , JAK , BTK
	LFM-A13（IC50=2.5 μM）, a specific Bruton's tyrosine kinase (BTK), is more than 100-fold specificity than other protein kinases, such as JAK1, JAK2, HCK, EGFR, and IRK.		PLK , JAK , BTK
T6282	GSK461364	GSK461364A	PLK
	GSK461364 (GSK461364A)(Ki=2.2 nM) inhibits purified Plk1 .The specificity of GSK461364 for Plk1 is more than 1000-fold over Plk2/3.		PLK
T14927	Centrinone	LCR-263	PLK , Aurora Kinase
	Centrinone (LCR-263) (LCR-263) is a reversible inhibitor of polo-like kinase 4 (PLK4; Ki:0.16 nM).		PLK , Aurora Kinase
T1839	Mps1-IN-2		Kinesin , PLK
	Mps1-IN-2 is a potent, selective and ATP-competitive dual Mps1/Plk1 inhibitor.		Kinesin , PLK
T2634	Ro3280	RO 3280,Ro5203280	PLK
	Ro3280 (Ro5203280) is an effective, specific inhibitor of PLK1(IC50=3, Kd=0.09 nM).		PLK
T2704	MLN0905	PLK1 Inhibitor	PLK
	MLN0905 (PLK1 Inhibitor) is an effective PLK1 inhibitor(IC50=2 nM).		PLK
T7200	TAK-960		PLK
	TAK-960 is an orally bioavailable, selective inhibitor of Plks with IC50 values of 0.8, 16.9, and 50.2 nM for Plk1, Plk2, and Plk3, respectively.		PLK
T21678	3MB-PP1		PLK
	3MB-PP1 is a bulky purine analog and a Polo-like kinase 1 (Plk1) inhibitor. In cells expressing analog-sensitive Plk1 alleles, 3MB-PP1 blocks mitotic progression and cell division arise by targeting Plk1. 3MB-PP1 specifi...		PLK
T16750	Rigosertib	ON-01910	Apoptosis , FLT , PLK , PI3K , Bcr-Abl , CDK , PDGFR , Src
	Rigosertib (ON-01910) is a selective and non-ATP-competitive inhibitor of PLK1 (IC50: 9 nM). Rigosertib is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition of the PI3 kina...		Apoptosis , FLT , PLK , PI3K , Bcr-Abl , CDK , PDGFR , Src
T5818	Rigosertib sodium	Rigosertib,Estybon,ON-01910	Apoptosis , PLK , PI3K
	Rigosertib sodium (ON-01910), a non-ATP-competitive inhibitor of PLK1(IC50=9 nM), exhibits 30-fold higher specificity activity over Plk2 and no effect on Plk3.		Apoptosis , PLK , PI3K
T2438	HMN-214	IVX-214,HMN214	PLK
	HMN-214 (IVX-214) is a potent PLK1 inhibitor with an average IC50 of 0.12 μM.		PLK
T6247	Onvansertib	NMS-P937,NMS-1286937	Apoptosis , PLK
	Onvansertib (NMS-1286937), an oral, specific Polo-like Kinase 1 (PLK1) inhibitor, is with IC50 of 2 nM. The specificity of NMS-P937 forPLK1 is 5000-fold higher over PLK2/PLK3.		Apoptosis , PLK
T19664	ON1231320	GBO-006	Apoptosis , PLK
	ON1231320 (GBO-006) is a Polo-like kinase 2 (PLK2) inhibitor.		Apoptosis , PLK
T6283	Wortmannin	SL-2052,KY-12420	ATM/ATR , DNA-PK , Serine/threonin kinase , PLK , PI3K , Antibiotic , Autophagy
	Wortmannin (SL-2052) is a PI3K inhibitor (IC50=3 nM) that is covalent and irreversible. Wortmannin is also an inhibitor of PlK1 and PlK3 (IC50=5.8/48 nM) that blocks autophagy.
T22288	(1E)-CFI-400437 dihydrochloride	CFI-400437 dihydrochloride	PLK
	(1E)-CFI-400437 dihydrochloride (CFI-400437 dihydrochloride) is a selective and potent polo-like kinase 4 (PLK4) inhibitor.		PLK
T2271	SBE13 Hydrochloride	SBE 13 hydrochloride,SBE 13 HCl	Apoptosis , PLK , Autophagy
	SBE13 Hydrochloride (SBE 13 HCl) is an effective and specific PLK1 inhibitor (IC50: 0.2 nM); no inhibition om Aurora A kinase, Plk2/3.		Apoptosis , PLK , Autophagy